Recently, the Institute of Molecular Medicine of Peking University used non-human primate models to find that mineralocorticoid receptor blockers can treat circadian rhythm disorders associated with hypertension, and propose new mechanisms for the treatment of hypertension and new drug evaluation indicators. .
It is understood that hypertension is one of the most common cardiovascular diseases in the clinic, often accompanied by functional or organic damage including various organs such as heart, brain and kidney, which seriously threaten human health. The regulation of blood pressure has obvious circadian rhythm. Arterial blood pressure generally decreases by 10-20% after falling asleep at night, and it rises rapidly in the morning, while the circadian rhythm of blood pressure in hypertensive patients, especially the decrease of blood pressure at night is significantly reduced.
Clinical evidence indicates that circadian rhythm disorder of blood pressure is closely related to the incidence and mortality of cardiovascular events in patients. Therefore, restoring blood pressure circadian rhythm is of great significance for the treatment of hypertension and its complications.
Since 2006, the Non-Human Primate Research Center of the Institute of Molecular Medicine of Peking University has established a variety of metabolic and cardiovascular disease models using rhesus monkeys. In this study, the hypertensive rhesus monkey model of spontaneous metabolic syndrome was established for the first time, and then the 24-hour blood pressure of awake rhesus monkeys was measured continuously for several months in real time using a surgically implanted blood pressure wireless telemetry system. It was found that the hypertensive rhesus monkey model of spontaneous metabolic syndrome not only increased blood pressure, but also significantly reduced the amplitude of nocturnal blood pressure. The use of the first-line clinical antihypertensive drug eplerenone (eplerenone) not only reduced blood pressure, but also significantly restored the amplitude of nighttime blood pressure reduction, improving the disorder of blood pressure circadian rhythm. At the same time, eplerenone also reduced the concentration of inflammatory factors and glycosylation end products in the blood.
It is reported that this study demonstrates for the first time in primate models that the improvement of disordered circadian rhythm is also an important factor in the treatment of hypertension and protection of the cardiovascular system by iprirenone, and the mechanism of action of new eplerenone is also found. The work was recently published online in the journal Scientific Reports. The research was supported by the National Natural Science Foundation of China, the 973 Project of the Ministry of Science and Technology, the National Science and Technology Major Project of the Ministry of Science and Technology, the Peking University-Tsinghua Life Science Joint Center, the National Key Laboratory of Biofilm and Membrane Biology, the Beijing Key Laboratory and the Merck East Company. .
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