For the first time, researchers at Duke University in the United States have produced human skeletal muscle that shrinks and responds to external stimuli, just as natural human tissue responds to external electrical impulses, biochemical signals, and drugs.
This laboratory-grown tissue will soon be available for researchers to test new drugs and study diseases on human basal muscles outside the body. The study was led by Nenad Bersek, an associate professor of biopharmaceutical engineering at Duke University, and Lauren Mayton, a postdoctoral researcher at the Bersec laboratory. The relevant results were released on the open source magazine "eLife" published on January 14 (Beijing time).
“The beauty of this work is that it can safely test the effectiveness of the drug without harming the patient's health, and it can also reproduce basic biochemical signals for diseases that are rare and difficult for muscle biopsy,†says Bersek.
Besek and Maiton started with a small piece of human cell specimens. Although they have surpassed the stem cell stage, they have not become muscle tissue. Then they have magnified this "muscle precursor" 1000 times and then placed it in a three-dimensional In the scaffolding support of the nutritional gel, this allows the muscle fibers to function.
“We have a lot of experience in making artificial muscles in the laboratory with animal cells, but it took us a year to adjust the relevant cells, gel density, and optimize the culture environment and medium for human muscles.†Said.
Mayton allowed this new type of muscle to undergo a series of tests. She found that muscle contraction was strong under electrical stimulation, which meant that the first human muscle was born in the laboratory. She also demonstrated that the signaling pathway that stimulates the muscles to the muscles works perfectly.
To see if this muscle could be used as a substitute for medical experiments, Bersek and Maiton studied their response to a variety of drugs, including statins used to lower cholesterol. The drug effect matches the effect on human patients.
“One of our goals is to use this method to provide patients with personalized medicine,†says Bersek. “We can take a biopsy from each patient and develop new muscles for each patient to see which one to observe. The drug is better able to play a better role."
This goal will not be realized too far. Bersek has conducted research with clinicians, and his team is experimenting with versatile induced stem cells instead of biopsy cells to culture and grow human contractile muscles.
DNA holographic imaging technology has long been considered the future of medicine, but there are few application cases. The appearance of the first artificial muscle is equivalent to the creation of a mirror image in vitro, and its application is much more than just a trial. In the future, when the first muscle tissue appears, the repair and functional regeneration of the human body will become a reality.
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