Air pollution needs to be vigilant or increase the risk of chronic kidney disease
August 29, 2016 Source: Health News
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];A team of academicians of the Southern Medical University, Hou Fanfan, recently published in the International Journal of Nephrology, the Journal of the American Society of Nephrology, showed that long-term exposure to high levels of PM2.5 increases membranous nephropathy (an autoimmune The frequency of onset of chronic kidney disease. The study confirmed for the first time that in addition to causing respiratory diseases, air pollution may also damage the immune system and increase the risk of chronic kidney disease.
The World Health Organization's 2015 announcement shows that 8 million people worldwide die from air pollution every year. The impact of air pollution on population health is most pronounced in East Asia and Southeast Asia. Previous medical research has confirmed that air pollution, especially high levels of PM2.5, can cause damage to the human respiratory and cardiovascular systems, increasing the risk of death, and the relationship between air pollution and kidney disease has not been reported globally.
Hou Fanfan team analyzed 71151 cases of renal biopsy pathological examination results and clinical information of 291 hospitals in 282 cities and 938 hospitals in China from 2004 to 2014. It was found that the risk of membranous nephropathy in China has increased significantly in the past 11 years. After adjusting for risk factors such as age and gender, the risk of membranous nephropathy increases rapidly at a rate of 13% per year, while the frequency of other types of nephropathy is relatively stable. At present, the incidence of membranous nephropathy is among the highest in China for chronic kidney disease. Chronic kidney disease has a risk of developing end-stage renal failure (uremia), which is considered a public health problem that consumes enormous health resources.
Dr. Nie Wei, from the Department of Nephrology, Nanfang Hospital, who participated in the study, said that the pathogenesis of membranous nephropathy has not yet been fully elucidated and may be related to various factors such as genes and environment. The rapid increase in the risk of membranous nephropathy in a short period of time is difficult to explain with genetic susceptibility, so environmental factors have become the primary consideration for the research team. Further studies have shown that there are significant regional differences in the frequency of membranous nephropathy. In cities with severe air pollution in northern China, the risk of membranous nephropathy is significantly higher than in other regions. Studies have shown that in areas where PM2.5 levels in the air are above 70 μg/m3, for every 10 μg/m3 increase in PM2.5, the risk of membranous nephropathy increases by 14%.
The results of this study were recommended by the journal as an important finding in the academic community. Experts pointed out that the research results provide important scientific evidence for environmental protection and public health protection in many developing countries and regions including China. It is imperative to take active measures to monitor and reduce air pollution, so as to prevent and control clinical diseases related to this.
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