"In the future, human organ chips may be able to replace our animal experiments and become a promising research tool." In an interview with reporters, Qi Duanqing, dean of the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, could not conceal the human organ chip. The enthusiasm of the new field.
He said that with the recent microfluidic chip research group of the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences using organ chip technology to successfully construct a dynamic three-dimensional high-throughput blood-brain barrier model, the concept of human organ chips has entered people's field of vision.
Evaluation of efficacy with organ chips
The development of a new drug must first pass animal experiments, then enter clinical trials, and it is proven to be safe and effective before it can be approved for marketing. However, there are differences in the response of animals to drugs and the response of humans to drugs, which has caused defects in drug screening in animal experiments.
To this end, an organ chip that combines electronic technology and biological science technology has entered the field of biomedicine. This biochip containing human living cells is a combination of microfluidics, cell biology, biomaterials and stem cell technology. As a functional type of micro-tissue organ, organ chips are used for research on efficacy evaluation.
Yan Duanqing pointed out that in China, this technology is still in the exploration stage, but it is very worthy of recognition. “Because the human body evaluates the drug response, the data it provides is closer to the human body than the animal model.â€
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