The pharmaceutical water system involves many related technical applications. Heat exchange technology is very important as one of them. It is not only related to the smooth operation of the entire water system, but also related to the product quality and operation and maintenance cost of the water system. Risk control such as the limits of microorganisms. Therefore, there are different forms of heat exchanger applications in the various process steps from production to distribution of pharmaceutical water.
The preparation process of the pharmaceutical water in the preparation process, that is, the purification process of water. The design of the purification process must be based on the water quality of the source water and the water quality requirements of the final water point. The purification process usually consists of more or less purification modules. Usually, the process is pretreatment from source water, to demineralized water, and further purified to obtain purified water and water for injection.
There are two general applications for heat exchangers in this process. One is to periodically pasteurize the pretreatment system during the pretreatment phase; the other is to perform pasteurization of the water constant temperature and purification system before the RO system before the RO.
Here, in the whole preparation process, the system is all drinking water or softened water, and the plate heat exchanger is mostly used.
Storage and Distribution Once the water has been purified, it needs to be stored and distributed to each point of use. This storage and distribution system is designed according to the layout of the plant and the water quality requirements for storage and distribution.
There are usually three main storage and distribution systems: hot water, room temperature water and cold water systems. In addition to these three, there are many different storage and distribution system designs. However, the design of all pharmaceutical water systems has a common requirement, and it is also a strict feature of its zui, which is to reduce the potential risk of external pollution to low. The risk of contamination in the distribution system is the risk of microorganisms. Effectively controlling the temperature change of the water storage and distribution system is one of the important measures to control the microbiological risk. Therefore, in the storage and distribution system, in order to meet the requirements of cGMP, it is necessary to adopt The double-tube plate heat exchanger has functions such as preventing cross-contamination, exhausting the product side, and leak detection.
The common storage and distribution systems for zui are purified water and water for injection:
Purified water (PW) stores and distributes the general purified water system to a bactericidal state. In order to control the growth and reproduction of microorganisms in the distribution system, the water system should be cleaned and disinfected regularly, or a certain operating temperature is guaranteed to prevent the growth and reproduction of microorganisms. Therefore, a heat exchanger is installed in the main circulation line to complete the pasteurization of the entire system, or to maintain the constant temperature of the entire purified water system to slow down the growth of microorganisms in the purified water.
Injection Water (WFI) Storage and Distribution Typically, a heat exchanger is installed at the end of the main circulation line to warm the back water or to sterilize the entire system.
The injection water is stored at high temperature and high temperature cycle (70~80 °C). When the use point requires cold injection water, it needs to be cooled. There are two kinds of conventional treatment methods:
1. Single point cooling, add heat exchanger after U-bend water point. This method has the advantages of easy installation, manual operation and long-term use of cold injection water, which will not affect the temperature of the main pipeline system, but The disadvantage is that the heat exchanger should be treated before each use of cold injection water, because the heat exchanger is empty to clean before use, and the corresponding verification is required. 2. The small circulation mode small circulation mode solves the heat treatment before each use. The problem with the device, but it also brings other drawbacks:
In order to balance the pressure, it is necessary to install a restrictor valve or a orifice plate on the main circulation pipe, which will increase the resistance of the main circulation pipe, thereby increasing the head of the main circulation pump and increasing the running cost;
In order to ensure the fluidity of the branch line of the small cycle, some of the cooled injection water must be returned to the main circulation line, which will inevitably affect the downstream use point temperature;
Energy consumption, because some of the cooled injection water returns to the main circulation line again, meaning that some of the refrigerant is consumed in vain, and this part of the cooled injection water needs to be heated and warmed before entering the storage tank. Storage tanks, so steam consumption will also increase;
To balance the pressure of the entire injection water line system, it is difficult to ensure the pipe flow rate for each branch section.
With the development of technology, new technologies are gradually applied to the water system. The combination of tube-and-tube heat exchangers and pitot tube connection methods, the entire heat exchanger is made of three layers of seamless steel tubes of different sizes. The three-layer pipe is bent into a 180o U-shape, and the three-layer pipe is molded at one time without risk of leakage (no internal welding). The product passes through the intermediate passage, and the cooling medium passes through the inner and outer tubes of the product.
The tube-in-tube heat exchanger is connected to the main pipe of the injection water system through the pitot tube, which forms a circulation by itself, and reduces the resistance of the main pipe compared with the conventional heat exchanger with small circulation type installation, thereby saving the main circulation pump. Load and save operating costs.
The modular product design solves all the shortcomings of single-point cooling of injected water under small flow conditions. This type of heat exchanger is now widely used in single-point cooling of injection water when the flow rate is less than 1500L/h. The heater is cycled online and disinfected online. The installation and operation are convenient. After the transformation, the whole module has no stagnant water during use, how much water is used to cool down, and there is no problem of returning cold injected water back to the main circulation pipeline.
Also known as electronic chemical materials. Generally refers to the electronics industry uses specialized chemicals and chemical materials, that is, electronic components, printed circuit boards, industrial and consumer production and packaging of various chemicals and materials. It can be divided into substrates, photoresists, electroplating chemicals, packaging materials, high purity reagents, specialty gases, solvents, pre-cleaning dopants, flux masks, acids and etchants, electronic adhesives and auxiliary materials Other categories. Electronic chemicals with many varieties, high quality requirements, small dosage, demanding on the cleanliness of the environment, product replacement fast, large capital investment, higher value-added products, etc., these characteristics with the development of micro-processing technology more and more obvious.
Electronic chemicals, also referred to as electronic chemical materials, refer to the fine chemical materials that are used in the electronics industry. The electronic chemicals are a kind of special chemicals. As far as the properties of the production process are concerned, they belong to the fine chemical industry. In terms of product use, Belongs to the electronic material industry. According to the classification standard of China's national economy, the electronic chemicals industry belongs to "Specialized Chemical Products Manufacturing Industry" (2662); according to the "Guidelines for Industry Classification of Listed Companies" promulgated by China Securities Regulatory Commission in April 2001, it belongs to "Specialized Chemical Products Manufacturing Industry" C4360 ). They include integrated circuits and discrete device chemistries, such as chip production photoresist, ultra-clean high-purity reagents, ultra-clean high purity gas, plastic packaging materials; color TV with chemical materials, such as color phosphor, CPT Supporting the water-soluble resist, high-purity inorganic salts, organic films, etc .; chemical materials used in printed circuit boards, such as dry film resist, ink, chemical and electroplating copper plating solution and its additives, surface mount process conductive paste , Cleaning agents, liquid solder resist photoresist, adhesive patch, conductive adhesive, solder paste, pre-coated flux, clean and water-based process flux; liquid crystal display devices with chemical materials, such as liquid crystal, photoresist , Oriented films, adhesives, slurries, electrolytes, films and encapsulants, polarizers, etc .; polishing materials, ect.
Surface Active Agent Tc-1000,Surface Active Agent Tc-2000,Surface Active Agent,Electronic Chemicals
Shandong Tiancheng Chemical Co., Ltd. , https://www.akdchemical.nl