1 pine pieces are not sticky enough (too much powder) - re-granulation with binder;
Excessive oily ingredients in the raw material - add the absorbent (CaHPO4, CaCO3, etc.) as the active ingredient;
It is an ineffective ingredient to remove oil;
Improper water content of the particles - the particles are deformed when the particles are dry and too wet, and the tablets are hard. The water content is preferably 3%-5%;
The concentration of ethanol in the granulation is too high; the length of the punch is not uniform; after the tablet is pressed, it is exposed to the air for too long, and the swelling of the water also produces pine pieces.
2 The adhesive particles are too wet, the lubricant is insufficient or unevenly distributed; the die has a word or roughness.
3 Disintegration time limit exceeded: pressure and hardness are important factors affecting the time limit of disintegration;
The effect of starch: starch can make insoluble or hydrophobic drugs disintegrate faster, but the effect of water-soluble drugs is poor;
The adhesive has strong adhesive force and a large amount of use, which can make the disintegration time limit exceed the limit;
The amount of lubricant used is too large to make the disintegration time limit exceed the limit;
Sugar-containing tablets significantly prolonged disintegration after storage at a high temperature or after wetting.
4 lobes:
Excessive fine powder or insufficient binder or too coarse and fine particles can cause cracks - sieving fine powder, drying adhesive and evenly pressing (CMC, microcrystalline cellulose, etc.);
More oil, more cellulose - add absorbent or powdered sugar;
The granules have small water content and are dry - spray ethanol to absorb moisture;
Excessive pressure or too fast speed 5 pieces of weight difference overrun: uneven grain thickness, unbalanced feeder, inflexible undershoot.
6 laminations: sticking or burring, etc., so that the tablet sticks to the upper punch and the lower punch rises too low.
7 discoloration or surface spots: the particles are too hard, the lubricant is not uniform, and there is too much oil on the top.
Excessive oily ingredients in the raw material - add the absorbent (CaHPO4, CaCO3, etc.) as the active ingredient;
It is an ineffective ingredient to remove oil;
Improper water content of the particles - the particles are deformed when the particles are dry and too wet, and the tablets are hard. The water content is preferably 3%-5%;
The concentration of ethanol in the granulation is too high; the length of the punch is not uniform; after the tablet is pressed, it is exposed to the air for too long, and the swelling of the water also produces pine pieces.
2 The adhesive particles are too wet, the lubricant is insufficient or unevenly distributed; the die has a word or roughness.
3 Disintegration time limit exceeded: pressure and hardness are important factors affecting the time limit of disintegration;
The effect of starch: starch can make insoluble or hydrophobic drugs disintegrate faster, but the effect of water-soluble drugs is poor;
The adhesive has strong adhesive force and a large amount of use, which can make the disintegration time limit exceed the limit;
The amount of lubricant used is too large to make the disintegration time limit exceed the limit;
Sugar-containing tablets significantly prolonged disintegration after storage at a high temperature or after wetting.
4 lobes:
Excessive fine powder or insufficient binder or too coarse and fine particles can cause cracks - sieving fine powder, drying adhesive and evenly pressing (CMC, microcrystalline cellulose, etc.);
More oil, more cellulose - add absorbent or powdered sugar;
The granules have small water content and are dry - spray ethanol to absorb moisture;
Excessive pressure or too fast speed 5 pieces of weight difference overrun: uneven grain thickness, unbalanced feeder, inflexible undershoot.
6 laminations: sticking or burring, etc., so that the tablet sticks to the upper punch and the lower punch rises too low.
7 discoloration or surface spots: the particles are too hard, the lubricant is not uniform, and there is too much oil on the top.
Corn tastes sweet, bland ,and can used for both food and feed.It has strong diuretic , detumescent, cholagogic and hemostatic effect, and can promote bile secretion. It also can cure diabetes and high blood pressure , hypertension, jaundice hepatitis and cholelithiasis, nephritis oedema and ascites of liver cirrhosis and other adverse symptoms of urination.
China Chongqing Pangfanyi Technology Co.,Ltd. , https://www.pangfany.com