Brief description of pharmaceutical packaging technology: thin film like butterfly wings

User-oriented packaging projects are not only limited to the standardization of packaging technology, but the new packaging process has also opened up new application channels. The Striptabs film with the active ingredient of the drug dissolves under the tongue, while the Catch-Cover tray-free, easy-to-carry single-plate package replaces the traditional carton pack. Rolf-DieterNiebel of Romaco Siebler in Karlsvo, Germany, introduced the new packaging of Catch-Cover: "Basically, we are an engineering design company. At work, we recognize the paper-free Catch-Cover. The easy-to-carry single-package packaging method is becoming more and more important.” Based on the thermocompression bonding technology, the company can provide users with a variety of different packaging solutions and can provide different packaging materials. system. The end result of this “tailor-made” packaging technology solution can be seen from the newly developed Catch-Cover free-to-carton single-chip packaging method and Striptabs easy-to-carry single-film packaging form. . Rolf-DieterNiebel said: "In Europe, analgesics are available in 10, 20-pack and 50-pack. In Africa, Latin America or Southeast Asia, the opposite is true. They are all small packages. There are often illegal vendors selling such drugs on the street, on the roadside without any packaging, or selling analgesics one by one, which opens the door to the counterfeiting of analgesics. ."

Figure 1 Striptabs membrane in a few seconds into the sublingual, pharmaceutical active ingredients contained in the membrane in its upcoming release package <br> <br> with patent information

In the Catch-Cover cassette-free portable single-chip package, the patent information of the drug can be directly integrated into the * package of the drug. The medicine itself is packaged in strips of elastic aluminum plastic film of different sizes and shapes, and the four sides are thermally pressed to realize the small packaging unit of the medicine. In the Catch-Cover package, the tablets or films are covered by a thin aluminum film, and all information about the product is printed on the inside of the aluminum film. This type of packaging can replace the traditional corrugated carton packaging. The front and back sides of the aluminum film for packaging are firmly connected by the welds produced during the thermocompression bonding. For the convenience of patients, the front of the Catch-Cover package has a gap to facilitate the uncovering of the aluminum plastic film. The fully automatic Catch-Cover single-piece packaging is completed by a production line that integrates an aluminum-plastic film feeding system, hot-pressing equipment and cutting equipment. The Catch-Cover aluminum plastic film conveyed by the feeding mechanism is exactly the same size as the long strip packaging, and is first thermoformed in a long strip. At the subsequent cutting station, the single-packaged Catch-Cover tablets and films were cut into individual packaged products according to their size and size, and were finally handed over to the counting, sorting and transport stacking equipment. In fully automatic production, the production capacity of this line is 1200 Catch-Cover single-piece packaging per minute.

User-driven

Zui's new Striptabs easy-to-carry single-chip film packaging solution is also a good example of user-oriented product design. A thin, skin-like film is suitable for use as a carrier for the active ingredient of the drug. The absorption of the drug through the sublingual gland bypasses the process of the drug entering the digestive tract, thereby accelerating the speed at which the active ingredient of the drug acts in the human body. The thickness of the drug film is between 60 and 100 μm, which can dissolve in a few seconds and enter the central nervous system directly through the sublingual gland. Therefore, it is very suitable for hormone therapy and pain treatment. In principle, there are about 600 active ingredients that can be absorbed through the skin, so this method of packaging has a wide range of applications. It takes many molds to coat the active ingredient of the drug and package the film. Among them, the accuracy of the quantitative determination of the active ingredient of the drug must not exceed 5%. This precision quantitative control system has been developed for up to 3 months.

The * step of the production process of the entire production line is the processing of the active ingredients of the drug. This step is to mix the wet and dry medicinal active ingredients into a uniform, bubble-free pharmaceutical material. Continuous stirring and heating of the active ingredients and raw materials of the drug can ensure the uniform distribution of the active ingredients of the drug. This bubble-free homogenization process was developed by Romaco FrymaKoruma and guarantees absolutely accurate quantitative accuracy. The equipment at the second station was developed and produced by coating technology specialist Optimags. In this station, the raw material of the drug will be made into a wide, very thin sheet of thumb, ready for the production of the final product. The liquid pharmaceutical raw material applied to the plastic film was only 1 μm thick and was uniformly applied to the carrier with the aid of an adjustable coating blade. The film coated with the active ingredient of the drug passes through several drying devices, and the residual humidity is less than 15%. In such a state, the film can be subjected to the next production process.

Thin as a butterfly wings

The next station is Zui's competitive production station. This station typically produces up to 30% of unusable corners. However, in the process technology developed by Romaco Siebler, the proportion of raw materials that become waste is controlled to 5%. Considering that many expensive pharmaceutical active ingredients are being used more and more widely, this technology-saving technology is becoming more and more important. In order to cut the film, the roll of the film coated with the active ingredient of the drug is unrolled and fed into the thermocompression apparatus. The unrolled film roll is cut into small squares of 20 x 30 mm in this device, and the cut size is high precision. After a precise correction of the hobbing tool, it ensures that there is no extra material left on the edge of the unrolled film roll. The cut film is fed into the key station of the device, the rotating shuttle transport system. The weight of a piece of film is lighter than the wings of a piece of butterfly. The cut sheet of film has a neat edge that can be transported by a transport jaw. However, the clamp type transportation method may loosen or peel off the film applied to the plastic film. The newly developed technology separates these films according to the package size by means of a shuttle conveyor and places them on the plastic film for *packaging. It then enters a hot press with 10 hot press channels.

summary

With innovative packaging technology, we have the opportunity to use more and better ways of administering high-efficiency pharmaceutically active ingredients. Especially in Asia, people have realized that this process technology has great potential. A pharmaceutical production plant in India has purchased such a production line to complete the production and packaging of the film in a short period of time and put the drug on the market as soon as possible.

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