Antioxidants do not prevent macular degeneration

Release date: 2007-11-12

Antioxidants Cannot Prevent Macular Degeneration According to a recent study by Australian scholars in the Chinese Medical Forum, antioxidants and supplements in the diet have little preventive effect on the development of early age-related macular degeneration (AMD) in Westerners. The study was published in BMJ (2007, 335: 755).
Wong et al., University of Melbourne, Australia, believe that because the retina is particularly susceptible to oxidative damage, it is logically assumed that antioxidants can prevent AMD. To date, most research in this area has focused on the effects of antioxidants on slowing the progression of early AMD.
The team conducted a systematic review and meta-analysis of early prevention of early or aggressive AMD in dietary or supplemental antioxidants. Early AMD was defined as soft glass with or without retinal pigmentation.
The study included 9 prospective cohort studies and 3 randomized controlled trials (published in 1998-2006) with an average follow-up of 9 years. A prospective study of 1,878 early AMD occurred in a total of 149,203 people; one study evaluated the effects of dietary supplementation with antioxidants; other studies used an effective diet frequency questionnaire. A meta-analysis of these studies showed that antioxidants (including vitamins A, C, E, zinc, lutein, zeaxanthin, alpha and beta carotene, beta cryptoxanthin and lycopene) had no effect on the onset of early AMD. Similarly, three randomized controlled trials failed to show any benefit from the supplementation of antioxidants (vitamin E and beta carotene) for the prevention of AMD.
In addition, smoking is the only controllable risk factor for the well-known primary prevention of AMD. Smoking cessation helps prevent AMD.
Source: China Medical Tribune

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