Ischemic heart disease is a common and frequently-occurring disease that seriously affects human health, and endothelin plays an important role in the pathogenesis of myocardial ischemia/reperfusion injury. Recent studies have confirmed that endothelin and snake venom have a causal chromosomal structure and similar biological effects, while anti-venom Chinese herbal medicine can antagonize the death, boosting and vasoconstriction effects of endothelin-induced mice. Accordingly, Li et al. speculated that the traditional anti-venom Chinese herbal medicine has the characteristics of an endothelin antagonist, and thus has the potential to treat cardiovascular diseases such as myocardial ischemia/reperfusion injury. In order to verify this hypothesis, Li Yugui et al. composed the anti-venom traditional Chinese medicines such as motherwort and andrographis paniculata with cold nature, and formed Qingxinyin Recipe. Through in vitro and in vivo animal experiments and preliminary clinical observations, the anti-venom was discussed from various aspects. Protective effect of traditional Chinese medicine on myocardial ischemia and reperfusion injury.
Through experimental research, they found that Qingxinyin Recipe has obvious improvement on ischemic T wave and ST segment changes caused by pituitrin, and the control effect is dose-dependent; in the anti-ischemic and anti-oxidative effects, Qingxin It can improve the myocardial ischemia electrocardiogram (T wave reduction and ST segment down shift) induced by isoproterenol hydrochloride in rats, reduce the release of CK and LDH in ischemic cardiomyocytes, and significantly enhance myocardial SOD activity. The content of SOD decreased; in the myocardial infarct size and serum CPK, LDH, SOD, MDA in rats with myocardial ischemia/reperfusion injury, the myocardial infarct size was significantly reduced in the experimental animals of Qingxinyin Recipe group, and the Qingxinyin prescription was reduced. Serum MDA content has a significant effect; in the protective effect of tetrandrine on I/R injury, the drug can significantly improve cardiac function, and the application of tetrandrine can significantly inhibit the proliferation of vascular smooth muscle cells, cell count and 3H-TDR The incorporation value was significantly lower than that of the control group and the endothelin group. The endothelin + tetrandrine group significantly inhibited cell proliferation, and tetrandrine significantly inhibited the c-jun group of VSMC. Because of expression.
On the basis of experimental research, Li Yugui et al also clinically observed the effect of Qingxinyin Recipe on dynamic electrocardiogram in 56 patients with asymptomatic myocardial ischemia (SMI). The results showed that both the Qingxinyin Recipe group and the control group could significantly reduce the number of SMI episodes and the duration of SMI. The number of ST-segment depression episodes and the duration of ST-segment depression in Qingxinyin Recipe group were significantly different before and after treatment. The difference between the indicators before and after treatment was also significant. After treatment, the reduction of SMI episodes and the shortening of SMI duration in Qingxinyin Recipe group were significantly better than those in the control group, indicating that Qingxinyin Recipe has better anti-ischemic effect.
According to Li Yugui et al., the anti-myocardial ischemic mechanism of Qingxinyin Recipe, in addition to its anti-venom and anti-endothelin effects, may be closely related to its anti-platelet aggregation, microcirculation, and blood viscosity.
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