Successful development of a new black phosphorus drug controlled release system
July 19, 2018 Source: Shenzhen Advanced Institute
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, Yu Xuefeng, a researcher at the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, and Zhang Yufeng, a professor at the School of Stomatology, Wuhan University, have developed a drug controlled release system that is loaded with black phosphorus and barium chloride to effectively repair the femur defect in rats. The research results were published in Biomaterials on the topic of Near-Infrared Light-Triggered Drug Delivery System Based on Black Phosphorus for in vivo Bone Regeneration. The first author of the paper was Wang Xuzhu, a visiting graduate student of Shenzhen Advanced Institute, and assistant researcher Shao Jundong.
The problem of bone defects caused by tumors, trauma, etc. has always been a huge challenge for clinicians. At present, domestic and foreign scholars are mainly looking for a bone substitute material to effectively repair bone defects. Bismuth element is a kind of trace element that can effectively promote bone repair. Studies have shown that strontium complex hydroxyapatite, bioglass, etc. as bone substitute materials can repair bone defects well. However, the effective cesium ion release concentration in this bone substitute material cannot be precisely controlled. In recent years, the use of various exogenous stimuli such as electric fields, magnetic fields, ultrasound, etc. to control drug release has been extensively studied. Among them, near-infrared light can control drug release remotely and accurately because of its good tissue penetration ability. As a high-efficiency photothermal conversion material, black phosphorus has attracted much attention in the biomedical field in recent years due to its good biocompatibility and biodegradability.
In this study, the team prepared a polylactic acid (PLGA) microsphere loaded with black phosphorus and barium chloride and implanted it into a rat femoral defect model due to the photothermal conversion function of black phosphorus. Infrared light irradiation can cause local temperature rise to the glass transition temperature of PLGA (55 ° C), resulting in the rupture of PLGA microspheres, thus achieving controlled release of cesium ions. By adjusting the time and position of the irradiation, the cesium ions can be released at the optimal time and space, and the optimal drug effect can be achieved, thereby realizing the effective repair of the femur bone defect in rats (Fig.). This black phosphorus-based drug delivery system can be used not only for bone tissue regeneration, but also for various therapeutic systems that require precise drug controlled release.
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