Recently, Professor Li Yongsheng from the School of Materials Science and Engineering, East China University of Science and Technology, has made new progress in the field of anti-tumor nano-drugs in the field of nitric oxide (NO). The related work is "Dual intratumoral redox/enzyme-responsive NO-releasing nanomedicine for the specific, High-efficacy and low-toxic cancer therapy is published online on Advanced Materials.
Nitric oxide (NO), one of the smallest and simplest biologically active molecules in nature, can effectively inhibit tumor cell growth and cause apoptosis at high concentrations, thereby exhibiting antitumor activity. However, the low water solubility, physiological instability, short half-life and high toxic side effects of NO prodrugs have seriously hindered their application in tumor therapy. In order to solve these problems, the team prepared a high-anti-tumor NO prodrug NPQ loaded in a disulfide-bonded silicone-protected hybrid nanomicelle to prepare a dual response (redox response/ The enzyme responds to the release of nano-drugs of NO while simultaneously utilizing the imaging properties of the dye molecule QM-2 aggregation-induced luminescence (AIE) to monitor the distribution of nanomedicines in vivo.
Cell experiments show that the nano drug releases NO only in tumor cells, but not in normal cells. The IC50 value of the semi-inhibitory concentration on liver cancer cells is much lower than that of normal liver cells, showing specificity for liver cancer cells. Sexual killing effect. The results of in vivo experiments showed that the antitumor rate of nanomedicine was 45.5% at low dose (5 mg/kg), and the antitumor effect of pure NPQ with injection dose of 20 mg/kg (49.9%). Quite; when the nano drug injection dose was increased to 20 mg/kg, the tumor inhibition rate was as high as 84.4%, which is the best level among the passively targeted nano drugs currently loaded with a single drug. Fluorescence imaging results further show that the nano drug can be enriched in tumor tissues and has a good tumor targeting effect. In addition, the nano-medicine hybrid silicon layer can effectively prevent NPQ from non-enzymatic decomposition and release of NO in blood circulation and normal tissues, thereby avoiding side effects such as venous relaxation and blood pressure reduction caused by NO. This provides a new idea for the design of high-efficiency, low-toxic side effects for the treatment of tumor nanomedicine.
The work was mainly done by Jia Xiaobo, a doctoral student at East China University of Science and Technology, under the joint guidance of Professor Li Yongsheng and Professor Huang Zhangjian of China Pharmaceutical University. The research was funded by the National Natural Science Foundation of China, the National Key Research and Development Program, and the Shanghai Excellent Academic Leadership Program.
Amino acid plays an important role in human and animal nutrition and health. It has wide use and prospect market. we are decided to develop an amino acid derivative compounds according to the company 's own personnel expertise . Currently we focus on the development of amino acid derivatives. Amino acid derivative is a compound derived from sequence of reactions by amino acid, the predecessor of the amino acid derivative is an amino acid. Under leading by Massachusetts Institute of Technology Dr. Wanghong Yao , synthesis tenology has continuous improvement, production process has continuous innovation. Our original synthesis method is on the transferring to the fermentation method , enzymatic method. Under strictly environmental pressure background, the method not only greatly reduce the pressure but also improve economic efficiency. Some of our products can reach production capacity in tons, we will take reasonable measures to try to meet the market demand , and strive to achieve on time delivery , delivery asap in timely period .
we will give you:
1. Best quality in your requirement
2. Competitive price in China market
3. Mature Technical support
4. Professional logistic support
All we want is win-win business. Send yr. inquiries, you will get it!
Amino Series, Humic Amino Acid Granule,Humic Amino Granule
Taizhou Volsen Chemical Co., Ltd. , https://www.volsenchem.com