According to a latest developmental study published online by the UK's Nature magazine on the 23rd, the Organist, a group of cells that has long existed in the theoretical hypothesis to help organize and direct embryonic development, has been shown for the first time. Exist in human tissues. The study provides a new model for early embryonic development and establishes a system that will facilitate the understanding of how these cells work.
In 1924, Hans Speiman, a pioneer in the area of ​​experimental embryology, and Hilde Mangold, the “mother of embryologyâ€, teamed up to transplant a small piece of tissue from a quail embryo into another quail embryo. After the soft tissue was found, it induced the host cell to form another embryo, that is to say, the original soft tissue of the host would gradually develop into the kind of soft tissue that had been transplanted. They call the transplanted area an "organizer" because it can organize host cells around it and guide the cells to develop as needed.
"Organizer" has always existed in the theoretical hypothesis of biology and is considered as a group of cells that help organize and direct the development of embryos. Until recently in a new study, scientists demonstrated for the first time that they actually existed in the human body through human stem cell experiments.
Ali Brevinlow, a researcher at Rockefeller University in the United States, and colleagues used special microplates to culture human embryonic stem cells and use growth factors to treat them. Growth factors induce these stem cells to form "organizer"-like tissues. Then, the cell population was transplanted into chick embryos, and as a result, the surrounding host cells were induced to form slender nerve tissue, showing its tissue ability. Researchers said that "organizers" should be highly conserved in the animal world, with little or no change in long-term evolution.
Scientist Oliver Pelquil believes that the research team used human stem cells to obtain tissues that exhibited "organizer" characteristics, thereby establishing a system that can promote people to further understand how these cells function. (Reporter Zhang Mengran)
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