Circulation: Congenital heart defects in offspring increase maternal heart disease risk
April 8, 2018 Source: Biological Exploration of: Tierna
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, a new study of more than 1 million women showed for the first time that newborns with congenital heart disease have a higher risk of heart disease (including heart attack and heart failure) after many years.
Image source: Pixabay
It seems a bit far-fetched to use newborns as a long-term indicator of maternal heart health, but a new study by McGill University and the University of Montreal Hospital Research Center found that women who have congenital heart disease have cardiovascular disease in later life. The risk will increase. The results of this new study were published in an article entitled "Long-Term Risk of Cardiovascular Disease in Women Who Have Had Infants With Heart Defects" in April. Published on the 2nd in the journal Circulation.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.030277
The author of the paper, Nathalie Auger, an epidemiologist at the University of Montreal Hospital Research Center, explained: “Caring for infants with severe heart defects is associated with psychosocial and economic stress, which may increase the long-term risk of cardiovascular disease in the mother.â€
1 , method
The researchers analyzed data on women who gave birth in Quebec, Canada, from 1989 to 2013 (a total of 1,084,251 infants with severe, non-severe or no cardiac defects), tracking these women's future cardiovascular The hospitalization of the disease, the follow-up period of up to 25 years.
The authors explained: "We calculated the incidence of cardiovascular hospitalization per 1,000 people per year by adjusting the age of the sample, parity, pre-eclampsia, comorbidities, loss of maternal love, and time, and using Cox proportional hazard regression to estimate the infant. The risk ratio between heart defects and maternal cardiovascular hospitalization and 95% confidence intervals (CIs)."
2 , the results
When the team compared the mothers of infants with no congenital heart defects to the mothers of infants with heart problems, they found that women with severe heart defects in their offspring were 43% more likely to be hospitalized for cardiovascular disease. In addition, scientists have found that women with non-serious defects in infants are at a 24% higher risk of cardiovascular disease.
Studies have shown that the relationship between infant heart defects and cardiovascular disease after maternal pregnancy is not known, nor can genetic factors be ruled out. In addition, since 85% of infants with heart defects are now pubertal, the psychosocial effects of congenital heart disease comparators may have a long-term cumulative effect.
3 , discussion
It is worth mentioning that this study has some limitations. For example, women are still very young at the beginning of the study, so for most people, the 25-year follow-up did not extend to postmenopausal, which ruled out cardiovascular disease. The highest risk period; in addition, because researchers use only existing medical data, there is a lack of specific risk information (such as weight and smoking status) that increases women's heart problems. In response to the above research gaps, the researchers pointed out that these are important factors that should be considered in future research.
4 , meaning
The study provides an opportunity for these mothers to benefit from early prevention strategies and counseling, thereby reducing the risk of cardiovascular disease – the leading cause of death among women.
In addition, early-stage treatments for children with heart defects and health care providers (such as obstetricians) who track mothers can help women understand and minimize the risk of illness.
Auger concludes: “For some high-risk factors that cause heart disease, such as smoking, obesity, and physical activity, these health care providers are the best choice to inform women and provide advice.â€
Digital And Video Microscope,Digital Microscope,Lcd Digital Microscope, Video Microscope
Ningbo ProWay Optics & Electronics Co., Ltd. , https://www.proway-microtech.com