Author: Zhang Qiang Release Date: 2019-02-25
A deep understanding of the body's antiviral mechanism is the key to resisting viral infections and responding to major epidemic prevention and control. The reporter was informed on the 24th that Dr. Li Tao and the academician Zhang Xuemin of the Military Medical Research Institute of the Academy of Military Sciences successfully discovered the important regulation mechanism of the cell "gate god", avian adenosine synthase (cGAS), against viral infection. The world's top academic journal "Cell" ("Cell") published a related research paper online.
Dr. Li Tao said that there are tens of millions of viruses, but no matter which kind of virus, the basic principle of invading the body is the same. That is, its own genetic material (such as DNA) will inevitably be brought into the host cell, which in turn will cause the body to quickly make a strong immune response against these foreign genetic material to eliminate the virus infection, even at the expense of itself. At the cost, this is the main cause of lethal inflammation caused by viral infection. Among them, the DNA receptor cGAS protein plays a key role in triggering immune and autoimmune reactions from the inside of the cell, and is therefore referred to as the cell "gate".
Academician Zhang Xuemin pointed out: "Looking for effective interventions in cGAS activity and exploring its regulatory mechanisms are essential for combating viral infections, prevention and control of major infectious diseases, and treatment of autoimmune diseases."
Around this key scientific issue, Dr. Li Tao and the team of Academician Zhang Xuemin launched a joint scientific research and found that acetylation modification is a key molecular event controlling cGAS activity, and reveals the regulation law behind it. With the specific participation of Dr. He Xinhua, a drug design expert, the researchers finally found that a century-old drug, aspirin, could force cGAS to acetylate and inhibit cGAS activity. The researchers then further validated their findings using the cells of experimental animals and AGS patients.
Academician Zhang Xuemin said: "This research will enable us to respond to major outbreaks in the future, not only to control known viral infections, but also to respond to unknown viral infections. It may be an autoimmune disease that is currently incurable. Provide treatment." (Reporter Zhang Qiang)
Source: Technology Daily
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