Synaptic research provides ideas for targeted drug development
August 03, 2018 Source: Health News
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Wang Guangfu, a researcher at the Life Science Center of Harbin Institute of Technology, has made important progress in regulating synaptic plasticity in signaling pathways. Related papers have recently been published in the famous neuroscience journal Neuron. Experts pointed out that this research provides new ideas for the development and development of related targeted drugs in the future.
Synapses are the sites that form connections between neurons, while synaptic plasticity refers to the ability to enhance and attenuate synaptic connections. Synaptic plasticity has different manifestations in people's learning and memory, including long-term potentiation, de-enhancement, and long-term inhibition. Previous studies have determined that the Ras family of small GTPases (ie, Ras, Rap2, and Rap1) can serve as molecular switches in the multi-signal transduction cascade, controlling the different forms of synaptic plasticity, respectively. However, Ras and Rap proteins are highly homologous in sequence and structure, can be activated by the same upstream signal, and can activate the same downstream effector. Therefore, the question of how signal molecules achieve signal diversity and specificity needs to be answered.
The subject group allowed the Ras or Rap protein to be specifically expressed on the endoplasmic reticulum, lipid raft, host membrane, lysosome or Golgi by targeted delivery methods; and then recorded by high resolution patch clamp. Wang Guangfu and colleagues found that Ras activates long-term potentiation signaling pathway through the endoplasmic reticulum and lipid rafts, while Rap2 and Rap1 act through the membrane and lysosome activation to enhance and long-term inhibition signaling pathways. This observation not only reveals that signal molecules achieve signal diversity and specificity through different signaling platforms in different subcellular structures, but also provides an accurate regulatory tool and an effective research strategy to facilitate development. Target drugs precisely to treat a variety of diseases. (Reporter Yi Xiaofeng)
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